With increasing awareness about malignancies ,treatment advances in malignancies and increased life expectancy in patients with malignant disease, renal dysfunction which was not addressed earlier know has gained much importance.In this background we observed clinical profile of patients with AKI(Acute Kidney Injury) with background malignancy.

A total of 200 cancer patients with AKI admitted in Basavatarakam Indo American Cancer hospital, Hyderabad, India were studied.

Out of 200 patients in the study, mean age of the patients was 54.76 years. RENAL BIOPSIES IN PATIENTS WITH MALIGNANCY Renal biopsy was done in 9 patients, where cast nephropathy was seen in patients with multiple myeloma, chronic tubulointerstitial nephritis was seen in amyloidosis, ATIN(acute tubule interstitial nephritis) and ATN(acute tubular necrosis) was seen in lung cancer, membranous nephropathy and acute interstitial nephritis was seen in renal cell carcinoma and thrombotic microangiopathy was seen in a patient with AKI who underwent bone marrow transplantation for aplastic anemia. STAGES OF AKI Out of 200 patients in the study group, AKI of AKIN I was seen in 64 members, AKIN II was seen in 68 members and AKIN III was seen in 68 members. MALIGNANCY TYPES (N=200) Bladder cancer was common malignancy seen in 24 patients, followed by breast cancer, lung cancer and AML seen in 20 patients. CAUSES OF AKI IN PATIENTS WITH MALIGNANCY Multifactorial AKI was seen in 44 patients ,though each and every variant of malignancy has specific cause of AKI, sepsis was commonly seen in all types of malignancies. OUTCOMES...Figure 1

Sepsis was the common cause of AKI in many cancer variants. More the severity of AKI was associated with more adverse out comes. All types of AKI like pre-renal, intrinsic renal and obstructive element was seen in patients with AKI in the background of malignancy.