Chih-Chia Chen

• The Missing Link: Navigating the Acute Kidney Disease (AKD) Window and Preventing CKD
  Jei-Wen Chang Speaker The Missing Link: Navigating the Acute Kidney Disease (AKD) Window and Preventing CKDThe paradigm of acute kidney injury (AKI) has shifted dramatically over the past decade. Once regarded as a transient event, AKI is now recognized as the initiating step in a continuum that progresses through acute kidney disease (AKD) to chronic kidney disease (CKD). Representing the "missing link" in this spectrum, AKD—defined as persistent kidney dysfunction or injury lasting between 7 and 90 days after AKI—constitutes a critical, modifiable window during which timely intervention may interrupt disease progression and prevent irreversible kidney damage. This continuum is particularly pivotal in neonates and children. The developing kidney possesses unique developmental vulnerabilities, including incomplete nephrogenesis, reduced nephron endowment, and functional immaturity. Conditions such as prematurity, congenital anomalies of the kidney and urinary tract (CAKUT), hypoxic-ischemic injury, sepsis, congenital heart disease, and nephrotoxin exposure further compound the risk of maladaptive repair and incomplete recovery. Even following apparent clinical recovery, maladaptive repair and interstitial fibrosis may persist, increasing the lifelong risk of CKD, hypertension, and cardiovascular disease. This lecture will review the evolving concepts, epidemiology, and pathophysiological mechanisms of the AKI–AKD–CKD continuum, with an emphasis on neonatal and pediatric populations. Emerging biomarkers for the early detection of persistent kidney injury, risk stratification, and practical post-AKI management—including nephrotoxin stewardship, structured surveillance, and multidisciplinary follow-up—will be discussed. Recognizing AKD as a distinct clinical entity shifts the focus from treating AKI to promoting kidney recovery, offering a unique opportunity to preserve long-term kidney health and prevent CKD.

  Shotaro Matsumoto Moderator The Ultimate Support: Heart-Lung-Kidney Crosstalk and ECMO-CRRT Integration in PediatricsCore Decisions: Modality Selection (CVVH / CVVHD / CVVHDF) & Prescription
• Spotlight on Neonatal AKI: The AWAKEN Criteria, Unique Phenotypes, and Genetic Insights
  Chih-Chia Chen Speaker Spotlight on Neonatal AKI: The AWAKEN Criteria, Unique Phenotypes, and Genetic Insights

  Shotaro Matsumoto Moderator The Ultimate Support: Heart-Lung-Kidney Crosstalk and ECMO-CRRT Integration in PediatricsCore Decisions: Modality Selection (CVVH / CVVHD / CVVHDF) & Prescription
• The Ultimate Support: Heart-Lung-Kidney Crosstalk and ECMO-CRRT Integration in Pediatrics
  Shotaro Matsumoto Speaker The Ultimate Support: Heart-Lung-Kidney Crosstalk and ECMO-CRRT Integration in PediatricsCore Decisions: Modality Selection (CVVH / CVVHD / CVVHDF) & Prescription

  Min-Hua Tseng Moderator
• Beyond Renal Replacement: Advanced Extracorporeal Blood Purification in Pediatric Sepsis
  I-Jung Tsai Speaker Beyond Renal Replacement: Advanced Extracorporeal Blood Purification in Pediatric Sepsis

  Min-Hua Tseng Moderator
• Q&A